Cytochalasin H

Cytochalasin H is a nature product that could be isolated from fungus Phomopsis sp. Cytochalasin H inhibits cell growth and induces apoptosis. Cytochalasin H has anti-angiogenic activity. Cytochalasin H is an antibiotic and has antibacterial activity[1][2][3].

Product Specifications

CAS Number

[53760-19-3]

UNSPSC

12352005

Hazard Statement

H300+H310+H330, H361

Target

Antibiotic; Apoptosis; Bacterial; Bcl-2 Family; Caspase

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/cytochalasin-h.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@]12[C@](/C=C/C[C@H](C)C[C@@](C)(O)/C=C/[C@H]2OC(C)=O)([H])[C@@H]3O)N[C@@H](CC4=CC=CC=C4)[C@]1([H])[C@H](C)C3=C

Molecular Formula

C30H39NO5

Molecular Weight

493.63

Precautions

H300+H310+H330, H361

References & Citations

[1]Ma Y, et, al. Cytochalasin H isolated from mangrove‑derived endophytic fungus induces apoptosis and inhibits migration in lung cancer cells. Oncol Rep. 2018 Jun;39 (6) :2899-2905.|[2]Yi JM, et, al. In Vivo Anti-tumor Effects of the Ethanol Extract of Gleditsia sinensis Thorns and Its Active Constituent, Cytochalasin H. Biol Pharm Bull. 2015;38 (6) :909-12.|[3]Jouda JB, et, al. Antibacterial and cytotoxic cytochalasins from the endophytic fungus Phomopsis sp. harbored in Garcinia kola (Heckel) nut. BMC Complement Altern Med. 2016 Nov 14;16 (1) :462.