Andrastin A
Andrastin A meroterpenoid compound, is a farnesyltransferase inhibitor. Andrastin A inhibits the efflux of anticancer compounds from multidrug-resistant cancer cells. Andrastin A can be isolated from Penicillium species[1][2].
Product Specifications
CAS Number
174232-42-9
UNSPSC
12352211
Target
Farnesyl Transferase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/andrastin-a.html
Solubility
10 mM in DMSO
Smiles
CC1=C[C@@]2([C@](C)(CC[C@@]3(C(C)([C@H](CC[C@]32C=O)OC(C)=O)C)[H])[C@@](C(OC)=O)([C@@]1(C4=O)C)C(C4C)=O)[H]
Molecular Formula
C28H38O7
Molecular Weight
486.60
References & Citations
[1]Nielsen KF, et al. Andrastins A-D, Penicillium roqueforti Metabolites consistently produced in blue-mold-ripened cheese. J Agric Food Chem. 2005 Apr 20;53 (8) :2908-13. |[2]Rojas-Aedo JF, et al. The Biosynthetic Gene Cluster for Andrastin A in Penicillium roqueforti. Front Microbiol. 2017 May 5;8:813.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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