AZD5213

AZD5213 is a selective and competitive human H3 receptor antagonist with a pKi value of 9.3 for hH3R. AZD5213 can be used for the research of sleep and cognitive regulation[1][2].

Product Specifications

CAS Number

[1119807-02-1]

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/azd5213.html

Solubility

10 mM in DMSO

Smiles

O=C(N)C1=CC=C([C@@H]2[C@@H](C(N3CCN(C4CCC4)CC3)=O)C2)C=C1

Molecular Formula

C19H25N3O2

Molecular Weight

327.42

References & Citations

[1]Schou M, et al. Discovery and Preclinical Validation of [ (11) C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor. ACS Chem Neurosci. 2016 Feb 17;7 (2) :177-84.|[2]Nikolic K, et al. Procognitive properties of drugs with single and multitargeting H3 receptor antagonist activities. CNS Neurosci Ther. 2014 Jul;20 (7) :613-23.