RAS GTPase inhibitor 1
RAS GTPase inhibitor 1 (example 51) is a RAS GTPase inhibitor with anti-tumor activity, extracted from patent WO2018212774A1. RAS GTPase inhibitor 1 (example 51) exhibits an EC50 less than 1 μM for at least one nucleotide exchange and an IC50 less than 1 μM in H727 cells[1].
Product Specifications
CAS Number
2252242-32-1
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ras-gtpase-inhibitor-1.html
Purity
99.70
Solubility
10 mM in DMSO
Smiles
CC[C@@H](NC1=C2C=CC=C(C3=CCNCC3)C2=NC(NC4=CC=C(F)C(Cl)=C4)=N1)C5CC5.O=C(O)C(F)(F)F
Molecular Formula
C27H28ClF4N5O2
Molecular Weight
565.99
References & Citations
[1]WATERSON, Alex G, et al. QUINAZOLINE COMPOUNDS AS MODULATORS OF RAS SIGNALING. Patent. WO2018212774A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
ACTH (Adrenocorticotrophic Hormone) (AH26), CF740 conjugate, 0.1mg/mL
Cytokeratin, LMW (AE-1), CF568 conjugate, 0.1mg/mL
Calponin-1 (CNN1/832), CF568 conjugate, 0.1mg/mL
