TGFBR1-IN-1

2170830-26-7

TGFBR1-IN-1 is an ALK5 inhibitor extracted from patent WO2018004290A1, Compound 33, has an IC50 of 10-100 nM[1].

TGF-β Receptor

Reference compound

TGF-beta/Smad

COVID-19-immunoregulation

Cancer; Inflammation/Immunology

https://www.medchemexpress.com/tgfbr1-in-1.html

10 mM in DMSO

O=C(C1=NN(C2=NC(C)=CC=C2)C(C3=CC=C4N=CSC4=C3)=C1)NC5=CC=C(O)C=C5

427.48

[1]Novel pyrazole derivative as alk5 inhibitor and uses thereof. WO2018004290A1.

Room temperature

No Development Reported