Ganoderic acid TR

Ganoderic acid TR is a broad-spectrum inhibitor of influenza neuraminidase enzymes (NAs) . Ganoderic acid TR has IC50 values of 10.9 and 4.6 μM for H5N1 and H1N1 NAs, respectively. Ganoderic acid TR is limited by cytotoxicity and shows only weak activity against Oseltamivir (HY-13317) -resistant H1N1 viruses and influenza B viruses[1].

Product Specifications

CAS Number

[862893-75-2]

UNSPSC

12352211

Target

Influenza Virus

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ganoderic-acid-tr.html

Purity

98.0

Solubility

DMSO : 5.5 mg/mL (ultrasonic; warming)

Smiles

CC1(C)C(CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@H](C)CC/C=C(C)/C(O)=O)C[C@H](O)[C@](C)4C3=CC[C@@]12[H])=O

Molecular Formula

C30H44O4

Molecular Weight

468.67

References & Citations

[1]Zhu Q, et al. Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design. Sci Rep. 2015 Aug 26;5:13194.