Cyanidin 3,5-diglucoside (chloride)

Cyanidin 3,5-diglucoside chloride is an anthocyanin. Cyanidin 3,5-diglucoside chloride inhibits inflammatory cytokines (IL-1α, IL-1β, and IL-6) expression and NO production. Cyanidin 3,5-diglucoside chloride inhibits the phosphorylation of STAT3, IκB, ERK, p38, and AKT. Cyanidin 3,5-diglucoside chloride inhibits high pressure-induced decrease in GLAST. Cyanidin 3,5-diglucoside chloride exerts anti-inflammatory and skin barrier modulating effects. Cyanidin 3,5-diglucoside chloride can be used in retinal research[1][2][3].

Product Specifications

CAS Number

[2611-67-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Akt; IKK; Interleukin Related; NO Synthase; p38 MAPK; PERK; STAT

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cyanidin-3-5-diglucoside-chloride.html

Purity

99.44

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC2=CC(O)=CC3=[O+]C(C4=CC=C(O)C(O)=C4)=C(O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)C=C23.[Cl-]

Molecular Formula

C27H31ClO16

Molecular Weight

646.98

Precautions

H302, H315, H319

References & Citations

[1]Chen X, et al. Cyanin Chloride Inhibits Hyperbaric Pressure-Induced Decrease of Intracellular Glutamate-Aspartate Transporter in Rat Retinal Müller Cells. J Ophthalmol. 2018;2018:6128470.|[2]Kim M J, Chung H S, Han Y J, et al. Anti-inflammatory and skin barrier regulation of cyanin chloride in TNF-α/IL-17A/IFN-γ-induced HaCaT psoriasis model. Biotechnology and Bioprocess Engineering, 2024, 29 (6) : 1048-1060.|[3]Benchagra L, et al. Antioxidant Effect of Moroccan Pomegranate (Punica granatum L. Sefri Variety) Extracts Rich in Punicalagin against the Oxidative Stress Process. Foods. 2021 Sep 18;10 (9) :2219.