ICT5040

ICT5040 is a small molecule CXCR4 antagonist (IC50=3.8 μM) . ICT5040 inhibits CXCL12-mediated proliferation and migration, and suppresses CXCL12-induced intracellular calcium mobilisation in U87 glioma cells[1].

Product Specifications

CAS Number

[215655-21-3]

UNSPSC

12352005

Target

CXCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ict5040.html

Solubility

10 mM in DMSO

Smiles

FC(C1=CC=C(C2=NN=C(SC)O2)C(C)=N1)(F)F

Molecular Formula

C10H8F3N3OS

Molecular Weight

275.25

References & Citations

[1]Vinader V, et al. Discovery and computer aided potency optimization of a novel class of small molecule CXCR4 antagonists. PLoS One. 2013 Oct 18;8 (10) :e78744.