ICT5040
Product Specifications
UNSPSC Description
ICT5040 is a small molecule CXCR4 antagonist (IC50=3.8 μM). ICT5040 inhibits CXCL12-mediated proliferation and migration, and suppresses CXCL12-induced intracellular calcium mobilisation in U87 glioma cells[1].
Target Antigen
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein;Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ict5040.html
Solubility
10 mM in DMSO
Smiles
FC(C1=CC=C(C2=NN=C(SC)O2)C(C)=N1)(F)F
Molecular Weight
275.25
References & Citations
[1]Vinader V, et al. Discovery and computer aided potency optimization of a novel class of small molecule CXCR4 antagonists. PLoS One. 2013 Oct 18;8(10):e78744.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-129094/ICT5040-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-129094/
Clinical Information
No Development Reported
CAS Number
215655-21-3
Curated Selection
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