ICT5040
ICT5040 is a small molecule CXCR4 antagonist (IC50=3.8 μM) . ICT5040 inhibits CXCL12-mediated proliferation and migration, and suppresses CXCL12-induced intracellular calcium mobilisation in U87 glioma cells[1].
Product Specifications
CAS Number
[215655-21-3]
UNSPSC
12352005
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ict5040.html
Solubility
10 mM in DMSO
Smiles
FC(C1=CC=C(C2=NN=C(SC)O2)C(C)=N1)(F)F
Molecular Formula
C10H8F3N3OS
Molecular Weight
275.25
References & Citations
[1]Vinader V, et al. Discovery and computer aided potency optimization of a novel class of small molecule CXCR4 antagonists. PLoS One. 2013 Oct 18;8 (10) :e78744.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR4
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