Sulfo-PDBA-DM4
Product Specifications
UNSPSC Description
Sulfo-PDBA-DM4 is a agent-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Sulfo-PDBA to make antibody agent conjugate (ADC). Sulfo-PDBA is a gluthatione cleavable linker.
Target Antigen
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sulfo-spdb-linker.html
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCC(C)(C)SSCCC(C(O)=O)S(=O)(O)=O)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)([H])O1
Molecular Weight
978.58
References & Citations
[1]Sun X, et al. Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates. Bioconjug Chem. 2017 May 17;28(5):1371-1381.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-128954/Sulfo-PDBA-DM4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-128954/
Clinical Information
No Development Reported
CAS Number
1461704-01-7
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Polyclonal DMP-1 Antibody [Janelia Fluor 646]](https://cdn.genprice.uk/genprice/genprice4.png)
41840121 3 x 1.0μg DNA
RPL7AP62 CRISPRa sgRNA lentivector (set of three targets)(Human)
Ask
View Details 