Mc-Leu-Gly-Arg
Product Specifications
UNSPSC Description
Mc-Leu-Gly-Arg is a cleavable ether linker for antibody-drug conjugates (ADC) design.
Target Antigen
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc-leu-gly-arg.html
Solubility
10 mM in DMSO
Smiles
O=C(O)[C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC(CCCCCN(C1=O)C(C=C1)=O)=O)=O
Molecular Weight
466.53
References & Citations
[1]Zhang D, et al. Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads. Bioconjug Chem. 2018 Feb 21;29(2):267-274.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-128927/Mc-Leu-Gly-Arg-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-128927/
Clinical Information
No Development Reported
CAS Number
2639874-49-8
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