Phortress (free base)
Phortress free base (NSC 710305) is a P450 CYP1A1-activated antitumor prodrug with antitumor activity[1]. Phortress free base leads to DNA damage and cell cycle arrest[2].
Product Specifications
CAS Number
741241-36-1
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/phortress-free-base.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C2=NC3=CC(F)=CC=C3S2)C=C1C)[C@@H](N)CCCCN
Molecular Formula
C20H23FN4OS
Molecular Weight
386.49
References & Citations
[1]Behrsing HP, et al. In vitro exposure of precision-cut lung slices to 2- (4-amino-3-methylphenyl) -5-fluorobenzothiazole lysylamide dihydrochloride (NSC 710305, Phortress) increases inflammatory cytokine content and tissue damage. Toxicol Sci. 2013 Feb;131 (2) :470-9.|[2]Trapani V, et al. DNA damage and cell cycle arrest induced by 2- (4-amino-3-methylphenyl) -5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells. Br J Cancer. 2003 Feb 24;88 (4) :599-605.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP1
Frequently Asked Questions
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