MC-VC (S) -PABQ-Tubulysin M
MC-VC (S) -PABQ-Tubulysin M is a synthetic ADC drug-linker conjugate composed of the tubulin polymerization inhibitor Tubulysin M (an ADC Cytotoxin) and MC-VC (S) - PABQ (an ADC linker) is connected. MC-VC (S) -PABQ-Tubulysin M is effective against multidrug-resistant lymphoma cell lines and tumors[1].
Product Specifications
CAS Number
2055896-86-9
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC; Microtubule/Tubulin
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc-val-cit-pab-tubulysin5a.html
Solubility
10 mM in DMSO
Smiles
CC(O[C@@H](C1=NC(C(N[C@H](C[C@H](C)C(O)=O)CC2=CC=CC=C2)=O)=CS1)C[C@H](C(C)C)N(C)C([C@@]([C@@H](C)CC)([H])NC([C@@H]3[N+](C)(CCCC3)CC4=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN5C(C=CC5=O)=O)=O)=O)=O)C=C4)=O)=O)=O
Molecular Formula
C66H96N11O13S
Molecular Weight
1283.60
References & Citations
[1]Leanna R Staben, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8 (10) :1037-1041.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Auristatin
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