MC-Val-Cit-PAB-dimethylDNA31

MC-Val-Cit-PAB-dimethylDNA31 is a agent-linker conjugate for ADC with potent antitumor activity by using dimethylDNA31, linked via the ADC linker MC-Val-Cit-PAB. DimethylDNA31 has effective bactericidal activity against persisters and stationary-phase S. aureus.

Product Specifications

CAS Number

[1639352-06-9]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mc-val-cit-pab-dimethyldna31.html

Purity

99.97

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(C=CC1=O)N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C2)=CC=C2C[N+](C)(C)C(CC3)CCN3C4=CC(OC(C5=N6)=C(NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@@H]([C@H](C)[C@@H](OC)/C=C/O7)OC(C)=O)=O)C(C8=C5C9=C(O[C@@]7(C)C9=O)C(C)=C8O)=O)=C6C(O)=C4)=O)=O)=O.[Cl-]

Molecular Formula

C78H101ClN10O19

Molecular Weight

1518.15

References & Citations

[1]Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8 (12) :1112-1119.