MC-Val-Cit-PAB-carfilzomib (iodide)
MC-Val-Cit-PAB-carfilzomib iodide is a agent-linker conjugate for ADC with potent antitumor activity by using carfilzomib (an irreversible proteasome inhibitor), linked via the ADC linker MC-Val-Cit-PAB.
Product Specifications
CAS Number
2055896-83-6
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc-val-cit-pab-carfilzomib.html
Purity
96.58
Solubility
DMSO : 230 mg/mL (ultrasonic)
Smiles
O=C([C@]1(CO1)C)[C@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](CC(C)C)NC([C@H](CCC3=CC=CC=C3)NC(C[N+]4(CCOCC4)CC5=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN6C(C=CC6=O)=O)=O)=O)=O)C=C5)=O)=O)=O)=O.[I-]
Molecular Formula
C68H96IN11O13
Molecular Weight
1402.46
References & Citations
[1]Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8 (12) :1112-1119.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Traditional Cytotoxic Agents
Frequently Asked Questions
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