MC-Val-Cit-PAB-carfilzomib (iodide)
MC-Val-Cit-PAB-carfilzomib iodide is a agent-linker conjugate for ADC with potent antitumor activity by using carfilzomib (an irreversible proteasome inhibitor), linked via the ADC linker MC-Val-Cit-PAB.
Product Specifications
CAS Number
[2055896-83-6]
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc-val-cit-pab-carfilzomib.html
Purity
96.58
Solubility
DMSO : 230 mg/mL (ultrasonic)
Smiles
O=C([C@]1(CO1)C)[C@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](CC(C)C)NC([C@H](CCC3=CC=CC=C3)NC(C[N+]4(CCOCC4)CC5=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN6C(C=CC6=O)=O)=O)=O)=O)C=C5)=O)=O)=O)=O.[I-]
Molecular Formula
C68H96IN11O13
Molecular Weight
1402.46
References & Citations
[1]Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8 (12) :1112-1119.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Traditional Cytotoxic Agents
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
302254 200 µL
AHCTF1 (Protein ELYS, Embryonic large Molecule Derived from yolk sac, Protein MEL-28, Putative AT-hook-Containing Transcription Factor 1, AHCTF1, ELYS, TMBS62)
Ask
View Details 
043126-HRP 200 µL
TOMM70A, NT (TOMM70A, KIAA0719, TOM70, Mitochondrial import receptor subunit TOM70, Mitochondrial precursor proteins import receptor, Translocase of outer membrane 70kD subunit) (Azide free) (HRP) discontinued
Ask
View Details