MC-Sq-Cit-PAB-Dolastatin10

MC-Sq-Cit-PAB-Dolastatin10 is a agent-linker conjugate for ADC with potent antitumor activity by using Dolastatin10 (a tubulin polymerization inhibitor), linked via the ADC linker MC-Sq-Cit-PAB.

Product Specifications

CAS Number

[1941168-65-5]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mc-sq-cit-pab-dolastatin10.html

Solubility

10 mM in DMSO

Smiles

C[N+]([C@H](C(N[C@H](C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C2=NC=CS2)CC3=CC=CC=C3)=O)CCC1)=O)C)=O)C(C)C)=O)C(C)C)(CC4=CC=C(NC([C@@H](NC(C5(C(NCCCCCN6C(C=CC6=O)=O)=O)CCC5)=O)CCCNC(N)=O)=O)C=C4)C

Molecular Formula

C70H105N12O12S

Molecular Weight

1338.72

References & Citations

[1]FLYGARE, John A, et al. Quaternary amine compounds and antibody-drug conjugates thereof. WO2016090050A1.|[2]Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8 (12) :1112-1119.