AZD5099

AZD5099, an antibacterial agent, is a potent and selective bacterial topoisomerase II inhibitor. AZD5099 potently inhibits the infections caused by Gram-positive and fastidious Gram-negative bacteria[1].

Product Specifications

CAS Number

[907543-25-3]

UNSPSC

12352005

Hazard Statement

H302

Target

Bacterial; Topoisomerase

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/azd5099.html

Solubility

10 mM in DMSO

Smiles

O=C(C(N=C(N(CC[C@H]1NC(C(NC(C)=C2Cl)=C2Cl)=O)C[C@@H]1OC)S3)=C3C(O)=O)N[C@@H](C)COC

Molecular Formula

C21H27Cl2N5O6S

Molecular Weight

548.44

Precautions

P264-P270-P330-P501

References & Citations

[1]Gregory S Basarab, et al. Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099) . J Med Chem. 2014 Jul 24;57 (14) :6060-82.