PROTAC ERRα Degrader-2

PROTAC ERRα Degrader-2 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-2 is an estrogen-related receptor alpha (ERRa) degrader[1].

Product Specifications

CAS Number

[2306388-85-0]

UNSPSC

12352005

Target

Estrogen Receptor/ERR; PROTACs

Type

Reference compound

Related Pathways

PROTAC; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-erralpha-degrader-2.html

Solubility

10 mM in DMSO

Smiles

O=C(N1[C@H]([C@H](N=C1C2=C(OC(C)C)C=C(C=C2)OC)C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl)N5CC(N(CC5)CC(NCCCCCNC(/C(C#N)=C/C6=CC(OC)=C(C=C6)OCC7=C(C(F)(F)F)C=C(C=C7)C(F)(F)F)=O)=O)=O

Molecular Formula

C57H55Cl2F6N7O8

Molecular Weight

1150.99

References & Citations

[1]Peng L, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation. ACS Med Chem Lett. 2019 Apr 12;10 (5) :767-772.