PROTAC ERRα Degrader-2
PROTAC ERRα Degrader-2 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-2 is an estrogen-related receptor alpha (ERRa) degrader[1].
Product Specifications
CAS Number
2306388-85-0
UNSPSC
12352005
Target
Estrogen Receptor/ERR; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-erralpha-degrader-2.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@H]([C@H](N=C1C2=C(OC(C)C)C=C(C=C2)OC)C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl)N5CC(N(CC5)CC(NCCCCCNC(/C(C#N)=C/C6=CC(OC)=C(C=C6)OCC7=C(C(F)(F)F)C=C(C=C7)C(F)(F)F)=O)=O)=O
Molecular Formula
C57H55Cl2F6N7O8
Molecular Weight
1150.99
References & Citations
[1]Peng L, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation. ACS Med Chem Lett. 2019 Apr 12;10 (5) :767-772.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MDM2
Frequently Asked Questions
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