Glucagon receptor antagonist-5
Glucagon receptor antagonist-5 (compound 13K) is a potent and orally bioavailable indazole-based glucagon receptor antagonist (Ki=32 nM) . Glucagon receptor antagonist-5 has potential for the treatment of type 2 diabetes mellitus (T2DM) [1].
Product Specifications
CAS Number
2200274-63-9
UNSPSC
12352005
Target
GCGR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/glucagon-receptor-antagonists-5.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCC(O)=O)C1=CC=C([C@@H](N2N=CC3=C2C=C(C)C(C4=CC=C(C(F)(F)F)C=C4Cl)=C3)CC(C)C)C=C1
Molecular Formula
C30H29ClF3N3O3
Molecular Weight
572.02
References & Citations
[1]Xu G, et al. Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2019 Oct 15;29 (20) :126668.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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