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Glucagon receptor antagonist-5

Glucagon receptor antagonist-5 (compound 13K) is a potent and orally bioavailable indazole-based glucagon receptor antagonist (Ki=32 nM) . Glucagon receptor antagonist-5 has potential for the treatment of type 2 diabetes mellitus (T2DM) [1].

Product Specifications

CAS Number

2200274-63-9

UNSPSC

12352005

Target

GCGR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/glucagon-receptor-antagonists-5.html

Solubility

10 mM in DMSO

Smiles

O=C(NCCC(O)=O)C1=CC=C([C@@H](N2N=CC3=C2C=C(C)C(C4=CC=C(C(F)(F)F)C=C4Cl)=C3)CC(C)C)C=C1

Molecular Formula

C30H29ClF3N3O3

Molecular Weight

572.02

References & Citations

[1]Xu G, et al. Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2019 Oct 15;29 (20) :126668.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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