DYRKs-IN-1

DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 has antitumor activity[1][2].

Product Specifications

CAS Number

[1387090-01-8]

UNSPSC

12352005

Target

DYRK

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dyrks-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC2=CN=C(N3CC(O4)CCC4C3)N=C2NC1=O)NC5=CC(C(NC(C6=CC=CC=C6)CCN)=O)=CC=C5Cl

Molecular Formula

C30H30ClN7O4

Molecular Weight

588.06

References & Citations

[1]Kevin Anderson, et al. Pyrido pyrimidines. US20120184542A1.|[2]Anderson K, et al. Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23 (24) :6610-5.