Mcl1-IN-9
Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM[1].
Product Specifications
CAS Number
1810769-31-3
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mcl1-in-9.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(CCCOC3=CC(C)=C(Cl)C(C)=C3)C4=CC=CC(C5=C(C)N(C)N=C5C)=C4N2CCCN1CC6=CC=CC(C(O)=O)=C6
Molecular Formula
C37H39ClN4O4
Molecular Weight
639.18
References & Citations
[1]Lee T, et al, Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. J Med Chem. 2019 Apr 25;62 (8) :3971-3988.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Mcl-1
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
YP-W77673-01 48 Tests
Bovine Calpain-1 catalytic subunit (CAPN1) ELISA Kit
Sign In for Pricing
View Details YP-W77673-02 96 Tests
Bovine Calpain-1 catalytic subunit (CAPN1) ELISA Kit
Sign In for Pricing
View Details 
EKC1068 1 Kit, containing one 96 Well Plate and all necessary reagents
BTK Colorimetric Cell-Based ELISA Kit
Sign In for Pricing
View Details