PD-1-IN-22

PD-1-IN-22 is a potent programmed cell death-1 (PD-1) /programmed cell death-ligand 1 (PD-L1) interaction inhibitor with an IC50 of 92.3 nM[1].

Product Specifications

CAS Number

[2349372-98-9]

UNSPSC

12352005

Target

PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pd-1-in-22.html

Purity

98.99

Solubility

10 mM in DMSO

Smiles

CC1=C(NC(C2=CC(CNCCO)=CN3C2=NN=C3)=O)C=CC=C1C4=CC5=C(OCCO5)C=C4

Molecular Formula

C25H25N5O4

Molecular Weight

459.50

References & Citations

[1]Qin M, et al. Discovery of [1,2,4]Triazolo[4,3- a]pyridines as Potent Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. J Med Chem. 2019 May 9;62 (9) :4703-4715.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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