PD-1-IN-22
PD-1-IN-22 is a potent programmed cell death-1 (PD-1) /programmed cell death-ligand 1 (PD-L1) interaction inhibitor with an IC50 of 92.3 nM[1].
Product Specifications
CAS Number
[2349372-98-9]
UNSPSC
12352005
Target
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pd-1-in-22.html
Purity
98.99
Solubility
10 mM in DMSO
Smiles
CC1=C(NC(C2=CC(CNCCO)=CN3C2=NN=C3)=O)C=CC=C1C4=CC5=C(OCCO5)C=C4
Molecular Formula
C25H25N5O4
Molecular Weight
459.50
References & Citations
[1]Qin M, et al. Discovery of [1,2,4]Triazolo[4,3- a]pyridines as Potent Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. J Med Chem. 2019 May 9;62 (9) :4703-4715.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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