BRD-IN-3
BRD-IN-3 ((R, R) -36n) is a highly potent PCAF bromodomain (BRD) inhibitor, with an IC50 of 7 nM. BRD-IN-3 also exhibits activity against GCN5 and FALZ[1].
Product Specifications
CAS Number
2351938-32-2
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brd-in-3.html
Solubility
10 mM in DMSO
Smiles
CN(C1)C[C@H](NC(N2C)=NC3=C(NC=C3)C2=O)C[C@@H]1C4=CC=C5OCCOC5=C4
Molecular Formula
C21H25N5O3
Molecular Weight
395.45
References & Citations
[1]Huang L, et al. Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain. J Med Chem. 2019 May 9;62 (9) :4526-4542.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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