ALK-IN-6
ALK-IN-6 (compound 11) is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK), with IC50 values of 71 nM, 18.72 nM and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L, respectively[1].
Product Specifications
CAS Number
2055821-33-3
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK)
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
ClC1=CN=C(NC2=C(OC([2H])([2H])[2H])C=C(C3CCNCC3)C(C)=C2)N=C1NC4=CC=CC=C4S(=O)(C(C)C)=O
Molecular Formula
C26H29D3ClN5O3S
Molecular Weight
533.10
References & Citations
[1]Das D, et al. Design, synthesis of orally bioavailable novel anaplastic lymphoma kinase (ALK) inhibitor diphenylaminopyrimidine analogs and efficacy study on NCI-H2228 xenografts mice model. Bioorg Med Chem Lett. 2019 Jun 15;29 (12) :1514-1517.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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