BACE1-IN-4
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer’s disease[1].
Product Specifications
CAS Number
2361157-92-6
UNSPSC
12352005
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bace1-in-4.html
Solubility
10 mM in DMSO
Smiles
NC1=N[C@@](C2=CC(NC(C3=NC=C(OCF)N=C3)=O)=CC=C2F)(C)C4(CCS(CC4)(=O)=O)CS1
Molecular Formula
C21H23F2N5O4S2
Molecular Weight
511.57
References & Citations
[1]Fujimoto K, et al. Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2. J Med Chem. 2019 May 23;62 (10) :5080-5095.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1
Frequently Asked Questions
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