CHMFL-KIT-033

CHMFL-KIT-033 is a potent and selective inhibitor of c-KIT T670I mutant for gastrointestinal stromal tumors (GISTs), with an IC50 of 0.045 μM[1].

Product Specifications

CAS Number

[2351801-41-5]

UNSPSC

12352005

Target

C-Kit

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/chmfl-kit-033.html

Concentration

10mM

Purity

99.74

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CC(NC1=CC=CC(F)=C1)=O)NC2=CC(NN=C3/C=C/C4=CC=CC=N4)=C3C=C2

Molecular Formula

C23H18FN5O2

Molecular Weight

415.42

References & Citations

[1]Liu X, et al. Discovery of (E) - N1- (3-Fluorophenyl) - N3- (3- (2- (pyridin-2-yl) vinyl) -1 H-indazol-6-yl) malonamide (CHMFL-KIT-033) as a Novel c-KIT T670I Mutant Selective Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs) . J Med Chem. 2019 May 23;62 (10) :5006-5024.