ALK-IN-5

ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK), with an IC50 of 2.9 nM[1].

Product Specifications

CAS Number

[2351929-66-1]

UNSPSC

12352005

Target

Anaplastic lymphoma kinase (ALK)

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/alk-in-5.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CN(C2=NNC(C)=C2)C3=NC(O[C@H](C4=NC=C(F)C=C4)C)=CC=C31)N5C[C@H](C)OCC5

Molecular Formula

C24H25FN6O3

Molecular Weight

464.49

References & Citations

[1]Fushimi M, et al. Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors. J Med Chem. 2019 May 23;62 (10) :4915-4935.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

FAB6942M 0.1 mL

Mouse Monoclonal GITR Ligand/TNFSF18 Antibody (109114) [DyLight 594]

Ask

View Details

MK202329 1 Kit

Gtse1 Mouse qPCR Template Standard (NM_013882)

Ask

View Details

CF502680 100 µg

RNF156 (MGRN1) Mouse Monoclonal Antibody [Clone ID: OTI1A8]

Ask

View Details

MBS7085853 Inquire

Recombinant Danio rerio Protein kish-B (tmem167b), partial

Ask

View Details

HY-RS24617 1 Set

Mstn Rat Pre-designed siRNA Set A

Ask

View Details