ALK-IN-5
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK), with an IC50 of 2.9 nM[1].
Product Specifications
CAS Number
2351929-66-1
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK)
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/alk-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN(C2=NNC(C)=C2)C3=NC(O[C@H](C4=NC=C(F)C=C4)C)=CC=C31)N5C[C@H](C)OCC5
Molecular Formula
C24H25FN6O3
Molecular Weight
464.49
References & Citations
[1]Fushimi M, et al. Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors. J Med Chem. 2019 May 23;62 (10) :4915-4935.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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