N-Desethyl amodiaquine-d5

N-Desethyl amodiaquine-d5 is the deuterium labeled N-Desethyl amodiaquine. N-Desethyl amodiaquine is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].

Product Specifications

CAS Number

[1173023-19-2]

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335, H413

Target

Isotope-Labeled Compounds; Parasite

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Field of Research

Infection

Purity

99.9

Solubility

10 mM in DMSO|DMSO : 100mg/mL (ultrasonic)

Smiles

ClC(C=C1)=CC2=C1C(NC3=CC(CNC([2H])([2H])C([2H])([2H])[2H])=C(C=C3)O)=CC=N2

Molecular Formula

C18H13D5ClN3O

Molecular Weight

332.84

Precautions

H301, H315, H319, H335, H413

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199 (11) :1575-82.