(Rac) -SAG

(Rac) -SAG is an isoform of SAG (HY-12848) . SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM) . SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo[1][2][3].

Product Specifications

CAS Number

[364590-63-6]

UNSPSC

12352005

Target

Smo

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rac-sag.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(Cl)C2=CC=CC=C2S1)N(C3CCC(NC)CC3)CC4=CC=CC(C5=CC=NC=C5)=C4

Molecular Formula

C28H28ClN3OS

Molecular Weight

490.06

References & Citations

[1]Guerrini G, et, al. Inhibition of smoothened in breast cancer cells reduces CAXII expression and cell migration. J Cell Physiol. 2018 Dec; 233 (12) : 9799-9811.|[2]Chen JK, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002 Oct 29;99 (22) :14071-6.|[3]Stanton BZ, et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009 Mar;5 (3) :154-6.|[4]Lee S, et al. Combining Smoothened Agonist (SAG) and NEL-like protein-1 (NELL-1) Enhances Bone Healing. Plast Reconstr Surg. 2017 Feb 13|[5]Fish EW, et al. Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice. Birth Defects Res A Clin Mol Teratol. 2016 Nov 1