AUTEN-67 (inner salt)

Product Specifications

CAS Number

[301154-74-5]

UNSPSC Description

AUTEN-67 (inner salt), the inner salt form of AUTEN-67 (HY-117924), is an orally active autophagy-enhancing agent and MTMR14 inhibitor with potent antiaging and neuroprotective effects. AUTEN-67 (inner salt) hampers the progression of neurodegenerative symptoms in a drosophila model of Huntington's disease[1][2].

Target Antigen

Autophagy

Type

Reference compound

Related Pathways

Autophagy

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/auten-67-inner-salt.html

Solubility

10 mM in DMSO

Smiles

O=C1C([N-]S(=O)(C2=CC=C([N+]([O-])=O)C=C2)=O)=C([N+]3=CNC4=C3C=CC=C4)C(C5=C1C=CC=C5)=O

Molecular Weight

474.45

References & Citations

[1]Diána Papp, et al. AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects. Autophagy. 2016 Feb; 12(2): 273–286.|[2]Viktor Billes, et al. AUTEN-67 (Autophagy Enhancer-67) Hampers the Progression of Neurodegenerative Symptoms in a Drosophila model of Huntington's Disease. J Huntingtons Dis. 2016 May 7;5(2):133-47.