CCT241161

CCT241161 is an orally active pan-RAF inhibitor with IC50s of 3, 6, 10, 15 and 30 nM for LCK, CRAF, SRC, V600E-BRAF and BRAF, respectively. CCT241161 shows good activity to in BRAF and NRAS mutant melanomas. CCT241161 also exhibits anticancer cell proliferative activity[1].

Product Specifications

CAS Number

[1163719-91-2]

UNSPSC

12352005

Target

Apoptosis; Raf; Src

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cct241161.html

Purity

99.77

Solubility

10 mM in DMSO

Smiles

O=C1C=NC2=C(N1)N=CC=C2OC3=CC=C(C(SC)=C3)NC(NC4=CC(C(C)(C)C)=NN4C5=CC=CC=C5)=O

Molecular Formula

C28H27N7O3S

Molecular Weight

541.62

References & Citations

[1]Girotti MR, et al. Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma. Cancer Cell. 2015 Jan 12;27 (1) :85-96.