KT-531
KT-531 is a potent and selective inhibitor of HDAC6 with an IC50 of 8.5 nM. KT-531 exhibits strong inhibition against SUP-T11 cells with an IC50 of 0.42 μM. KT-531 can be used in study hematological cancers[1].
Product Specifications
CAS Number
2490284-18-7
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kt-531.html
Solubility
10 mM in DMSO
Smiles
O=C(NO)C1=CC=C(CN(C2CC2)S(=O)(C3=CC(F)=C(F)C(F)=C3F)=O)C=C1
Molecular Formula
C17H14F4N2O4S
Molecular Weight
418.36
References & Citations
[1]Toutah K, et al. Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia. J Med Chem. 2021 Jun 24;64 (12) :8486-8509.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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