BTK inhibitor 8
BTK inhibitor 8 (Compound 27) is a Btk inhibitor with an IC50 of 0.11 nM. BTK inhibitor 8 inhibits B cell activation in hWB with an IC50 of 2 nM[1].
Product Specifications
CAS Number
2230724-66-8
UNSPSC
12352005
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/btk-inhibitor-8.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NOC(C(C)(C)C)=N1)NCC2=CC=C(C3=C4C(NC(C5=CN(C)N=C5)=C4)=NC=N3)C=C2F
Molecular Formula
C24H23FN8O2
Molecular Weight
474.49
References & Citations
[1]Musumeci F, et al. Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors. Expert Opin Ther Pat. 2017 Dec;27 (12) :1305-1318.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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