Ep300/CREBBP-IN-4
Ep300/CREBBP-IN-4 (Example 56) is a potent Ep300 and CREBBP inhibitor with IC50s of 0.024 and 0.064 μM, respectively. Ep300/CREBBP-IN-4 can be used for the research of cancer[1].
Product Specifications
CAS Number
2259641-42-2
UNSPSC
12352005
Target
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ep300-crebbp-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@H](C[C@H](C1)F)C(NC2=CC=C(NN=C3)C3=N2)=O)C4(C5=CC=C(C=C5)OC)CC(F)(C4)F
Molecular Formula
C23H22F3N5O3
Molecular Weight
473.45
References & Citations
[1]NAITO Hiroyuki, et al. EP300 / CREBBP inhibitor. Patent JPWO2018235966A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300
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