Ep300/CREBBP-IN-2
Ep300/CREBBP-IN-2 (Example 73) is a potent and orally active Ep300 and CREBBP inhibitor with IC50s of 0.052 and 0.148 μM, respectively. Ep300/CREBBP-IN-2 can be used for the research of cancer[1].
Product Specifications
CAS Number
[2259641-59-1]
UNSPSC
12352005
Target
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ep300-crebbp-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H]1N(C(C2(C3=CC=C(OC)C=C3)CCC(F)(F)CC2)=O)C[C@H](F)C1)NC4=CC=C(NC(C5)=O)C5=N4
Molecular Formula
C26H27F3N4O4
Molecular Weight
516.51
References & Citations
[1]NAITO Hiroyuki, et al. EP300 / CREBBP inhibitor. Patent JPWO2018235966A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300
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