MT-3014

MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively[1].

Product Specifications

CAS Number

[1332727-40-8]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mt-3014.html

Solubility

10 mM in DMSO

Smiles

CC(O)(C)CNC1=CC(N2C[C@H](F)CC2)=NC3=CC(C4=NC5=CC(F)=CC=C5N=C4C)=NN13

Molecular Formula

C23H25F2N7O

Molecular Weight

453.49

References & Citations

[1]Koizumi Y, et al. Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety. Bioorg Med Chem. 2019 Jun 19.