MT-3014
MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively[1].
Product Specifications
CAS Number
1332727-40-8
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mt-3014.html
Solubility
10 mM in DMSO
Smiles
CC(O)(C)CNC1=CC(N2C[C@H](F)CC2)=NC3=CC(C4=NC5=CC(F)=CC=C5N=C4C)=NN13
Molecular Formula
C23H25F2N7O
Molecular Weight
453.49
References & Citations
[1]Koizumi Y, et al. Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety. Bioorg Med Chem. 2019 Jun 19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE10
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
AP07781PU-N 50 µg
Sumo 1 (SUMO1) rabbit polyclonal antibody, Purified
Sign In for Pricing
View Details 