UDM-001651
UDM-001651 is a potent, selective, and orally bioavailable protease-activated receptor 4 (PAR4) antagonist (IC50=4 nM; Kd=1.4 nM) . UDM-001651 shows antiplatelet potency (IC50=25 nM) in a γ-thrombin-induced platelet-rich plasma aggregation assay (γ-Thr PRP) [1].
Product Specifications
CAS Number
1477497-01-0
UNSPSC
12352005
Target
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/udm-001651.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(OCC2=CC=CC(OCC3=CC=CC=C3)=C2)=C4C=C(C5=CN6C(SC(OC)=N6)=N5)OC4=C1
Molecular Formula
C28H23N3O5S
Molecular Weight
513.56
References & Citations
[1]Miller MM, et al. Discovery of Potent Protease-Activated Receptor 4 Antagonists with in vivo Antithrombotic Efficacy. J Med Chem. 2019 Jun 27.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAR4
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