Autogramin-1
Autogramin-1 potently inhibits autophagy induced by either starvation (IC50=0.17 μM) or mTORC1 inhibition (Rapamycin; IC50=0.44 μM) [1].
Product Specifications
CAS Number
[2375541-73-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/autogramin-1.html
Purity
99.79
Solubility
DMSO : 6.94 mg/mL (ultrasonic)
Smiles
O=C(N1)N(CCC)C(C2=C1C=C(C(NC3=NC(CCN(C(OC(C)(C)C)=O)C4)=C4S3)=O)C=C2)=O
Molecular Formula
C23H27N5O5S
Molecular Weight
485.56
Precautions
H302, H315, H319, H335
References & Citations
[1]Laraia L, et al. The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis. Nat Chem Biol. 2019 Jul;15 (7) :710-720.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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