2'-C-Methylguanosine

2'-C-Methylguanosine (2'-C-beta-Methylguanosine) is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) [1].

Product Specifications

CAS Number

[374750-30-8]

Product Name Alternative

2'-C-beta-Methylguanosine

UNSPSC

12352005

Hazard Statement

H301

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2-c-methylguanosine.html

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@](O)(C)[C@H](N2C=NC3=C2N=C(NC3=O)N)O[C@@H]1CO

Molecular Formula

C11H15N5O5

Molecular Weight

297.27

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100 (11) :6646-51.