LIMK1 inhibitor BMS-4

LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells[1][2].

Product Specifications

CAS Number

[905298-84-2]

UNSPSC

12352005

Target

LIM Kinase (LIMK)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/limk1-inhibitor-bms-4.html

Purity

98.05

Solubility

10 mM in DMSO

Smiles

O=C(NCC)NC1=NC=C(C2=CC(C3=C(C)C=C(C=C3C)OC)=NC(C4=NC=CN=C4)=N2)S1

Molecular Formula

C23H23N7O2S

Molecular Weight

461.54

References & Citations

[1]Collins R, et al. Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity. J Med Chem. 2022 Oct 27;65 (20) :13705-13713. |[2]Ross-Macdonald P, et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther. 2008 Nov;7 (11) :3490-8. |[3]Collins R, et al. Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity. J Med Chem. 2022 Oct 27;65 (20) :13705-13713.