Ftase inhibitor I
Product Specifications
UNSPSC Description
Ftase inhibitor I (B581) is a potent, selective and peptidomimetic farnesyl transferase (FTase) inhibitor. Ftase inhibitor I shows selectivity for FTase over geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras)[1].
Target Antigen
Farnesyl Transferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ftase-inhibitor-i.html
Solubility
10 mM in DMSO
Smiles
CSCC[C@@H](C(O)=O)NC([C@H](CC1=CC=CC=C1)NC[C@@H](NC[C@@H](N)CS)C(C)C)=O
Molecular Weight
470.69
References & Citations
[1]A D Cox, et al. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. J Biol Chem. 1994 Jul 29;269(30):19203-6.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-128044/Ftase-inhibitor-I-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-128044/
Clinical Information
No Development Reported
CAS Number
149759-96-6
Curated Selection
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