Cycloguanil
Cycloguanil, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].
Product Specifications
CAS Number
516-21-2
UNSPSC
12352005
Target
Drug Metabolite; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cycloguanil.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(N)=NC(C)(C)N1C2=CC=C(Cl)C=C2
Molecular Formula
C11H14ClN5
Molecular Weight
251.72
References & Citations
[1]Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105 (1) :190-200.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium
Citation 01
Pharmaceuticals (Basel) . 2024 Sep 19;17 (9) :1234.|Antimicrob Agents Chemother. 2025 Aug 18:e0047125.|bioRxiv. 2025 March 15.
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