Cycloguanil

Cycloguanil, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].

Product Specifications

CAS Number

[516-21-2]

UNSPSC

12352005

Target

Drug Metabolite; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/cycloguanil.html

Solubility

10 mM in DMSO

Smiles

NC1=NC(N)=NC(C)(C)N1C2=CC=C(Cl)C=C2

Molecular Formula

C11H14ClN5

Molecular Weight

251.72

References & Citations

[1]Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105 (1) :190-200.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Plasmodium

Citation 01

Pharmaceuticals (Basel) . 2024 Sep 19;17 (9) :1234.|Antimicrob Agents Chemother. 2025 Aug 18:e0047125.|bioRxiv. 2025 March 15.

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