Alimemazine

Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA) -receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays antiserotonin, antispasmodic, and antiemetic properties[1][2].

Product Specifications

CAS Number

[84-96-8]

Product Name Alternative

Trimeprazine

UNSPSC

12352005

Hazard Statement

H301-H317-H318-H411

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/alimemazine.html

Solubility

10 mM in DMSO

Smiles

CC(CN(C)C)CN1C2=CC=CC=C2SC3=CC=CC=C31

Molecular Formula

C18H22N2S

Molecular Weight

298.45

Precautions

P261-P264-P270-P272-P273-P280-P302+P352-P305+P351+P338-P330-P362+P364-P391-P405-P501

References & Citations

[1]Singh B, et al. Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies. J Pharm Bioallied Sci. 2013 Oct;5 (4) :257-64.|[2]Kuznetsova A, et al. Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice. JCI Insight. 2016;1 (3) .