Liproxstatin-1-15N

Liproxstatin-1-15N is the 15N labled Liproxstatin-1 (HY-12726) . Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM) [1].

Product Specifications

UNSPSC

12352005

Target

Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/liproxstatin-1-15n.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC(C[15NH]C2=NC3=CC=CC=C3NC24CCNCC4)=CC=C1

Molecular Formula

C19H21ClN3 15N

Molecular Weight

341.84

References & Citations

[1]Friedmann Angeli JP, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014 Dec;16 (12) :1180-91.|[2]Zilka O, et al. On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. ACS Cent Sci. 2017 Mar 22;3 (3) :232-243|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.