Apraclonidine

Apraclonidine (ALO 2145 (free base) ), a selective α2 and weak α1 receptor agonist activity, effectively low intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution[1][2].

Product Specifications

CAS Number

[66711-21-5]

Product Name Alternative

ALO 2145 (free base)

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/apraclonidine.html

Solubility

10 mM in DMSO

Smiles

NC1=CC(Cl)=C(NC2=NCCN2)C(Cl)=C1

Molecular Formula

C9H10Cl2N4

Molecular Weight

245.11

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Subhashie Wijemanne, et al. Apraclonidine in the treatment of ptosis. J Neurol Sci|[2]R V Searles, et al. Aqueous humor dynamics in anesthetized rats infused with intracameral apraclonidine. Pharmacology. 1999 Apr;58 (4) :220-6.|[3]Yoriko Hayasaka, et al. Effects of topical antiglaucoma eye drops on prostaglandin E (2) -induced aqueous flare elevation in pigmented rabbits. Invest Ophthalmol Vis Sci